Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

Reversible cell-specific drug delivery with aptamer-functionalized liposomes.

cis-Diamminedichloroplatinum(II) (cisplatin) is a potent chemotherapeutic agent for the treatment of a broad range of cancerous tumors. Despite its excellent antitumor efficacy, the major drawbacks of cisplatin include its lack of tumor specificity and severe side effects. In addition, certain tumor-cell types develop resistance to cisplatin from exposure to the drug. Strategies that allow the ...

Liposomes for Drug Delivery

Bergstrand, N. 2003. Liposomes for Drug Delivery: from Physico-chemical Studies to Applications. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertation form the Faculty of Science and Technology 826. 71pp. Uppsala.

Liposomes in topical drug delivery.

The possible use of liposomes as topical drug delivery vehicles for both water- and lipid-soluble drugs has been investigated. Data for two characteristic drugs, penicillin G and indoxole, are presented. Liposome uptake by the cornea is greatest for positively charged liposomes, less for negatively charged liposomes, and least for neutral liposomes, suggesting that the initial interaction betwe...

Liposomes in drug delivery: progress and limitations

Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Due to new developments in liposome technology, several liposomebased drug formulations are currently in clinical trial, and recently some of them have been approved for clinical use. Reformulation of drugs in liposomes has provided an oppor...

preparation and evaluation of superparamagnetic iron oxide nanoparticles coated with chitosan for targeting and controlled drug delivery of methotrexate